NF2 is passed down through families in an autosomal dominant fashion. This means that if one parent has NF2, any child of that parent has a 50-50 chance of having it.
The main risk factor is having a family history of the condition.
Symptoms of NF2 include:
Cataracts at a young age
Changes in vision
Coffee-colored marks on the skin
Ringing and noises in the ears
Exams and Tests
Brain and spinal tumors
Hearing-related (acoustic) tumors
Acoustic neuromas can be observed, or treated with surgery or radiation.
Patients may benefit from genetic counseling.
Every year, patients with NF2 should be evaluated with:
MRI of the brain and spinal cord
Hearing and speech evaluation
For information and support, visit http://www.nf.org.
NF2; Bilateral acoustic neurofibromatosis; Central bilateral acoustic NF
Ferner RE. Neurofibromatosis 1 and neurofibromatosis 2: a twenty first century perspective. Lancet Neurol. 2007;6:340-351.
Haslam RHA. Neurocutaneous syndromes. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 596.
Update Date: 10/14/2009
Updated by: Luc Jasmin, MD, PhD, Departments of Anatomy and Neurological Surgery, University of California, San Francisco, CA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.